I am not sure really whether this might help, but the only thing that seems even remotely useful I know of is the Win32::SerialPort module on CPAN - however, that one's not been updated in more than three years it seems, so it might have been superceded by another module.

Otherwise, you are mentioning some "com port libraries" - do these already exist (as a C library or something similar)? If yes, it shouldn't be too hard to write a wrapper module for Perl to utilize them.

I hope this helps a little bit at least!

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mowgli