in reply to ActiveState 5.8 debugger "Unable to connect to remote host: 127.0.0.1:2000"

Sounds like you have the RemotePort option set in an environment var PERL5DB_OPTS?

The relevamt bits from the output of the 'h o' command: 

 RemotePort          Remote hostname:port for remote debugging
 ...
 During startup options are initialized from $ENV{PERLDB_OPTS}.
 You can put additional initialization options TTY, noTTY,
 ReadLine, NonStop, and RemotePort there (or use
 `R' after you set them).

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