the DBI module allows you to specify a host machine in the DBI::connect() method. With Mysql, the first param to connect includes the options host, such as

...
    my $db_handle= DBI->connect("DBI:mysql:my_table:10.100.100.100", "
+user", "pass", ...)
        or die;
...
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Now, this assumes that you have set up the Mysql user permissions correctly...