Depending on what you want to do with it, Imager may or may not be useful. It handles the format specification using libtiff, but doesn't provide direct access to those functions. If you need a wrapper around libtiff, you could of course try Inline::C if you can't find a module that does exactly what you want.

Juerd # { site => 'juerd.nl', plp_site => 'plp.juerd.nl', do_not_use => 'spamtrap' }