I run perl using my special script named "runperl.pl" that will ease searching my own scripts where I usually place them.
Additionally that script allows to specify "--deb" option and required script will be called with "-d:ptkdb" option and will allow to do step-by-step debugging.

I use perlTk and Tcl::Tk as GUI, also I used to embed perl into my GUI programs with GUI provided by C++ Builder, but time passes and I refused to go that way nowadays.

There is a plenty of GUI engines that are available for Perl, and wxWindows, perlQt are only few of them, because perl has interconnection with really many systems (you can connect to Java and use it's GUI for example).

Courage, the Cowardly Dog