You can create a sub to check for an array of values that must not be inside a given string. This way, if you have more values, you can just add them to your array.

sub absent {
    my $str = shift;
    for (@_) {
        return 0 if $str =~ $_
    }
    return 1;
}

my @must_not_be_there = (
        '/bulletin/',
        '.css',
        'formmail.',
        '/prosp/',
        '/calendar/',
        '/edit/',
        '/tmp/calendar2002-3/pgradh/regs/029.html',
        'FalseIfJustThis',
        'ButIfAlsoThisThenTrue'
);

if (($ENV{'HTTP_REFERER'} 
    && $ENV{'REMOTE_ADDR'} ne "129.215.67.96")
    && absent ($ENV{'REQUEST_URI'}, @must_not_be_there) )
    {
        print "matches\n";
    }
[download]

Or simply use grep.

&&  !(grep {$ENV{'REQUEST_URI'} =~ $_} @must_not_be_there ) )
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