About 4.5-5 years ago, I started learning/using Perl/Tk. At the time, I found it much easier to use than any of the other GUI coding I'd done(1) -- which probably says more about the difficulty of those than about the ease of Tk. Since then, I've been doing web stuff and command-line stuff, and haven't explored the newer GUI development packages. I have heard good things about Wx over the past couple of years, though.

(1) Some C++ Win32 stuff in college, before I dropped the course. Windows API directly, IIRC, not MFC. And some C++ stuff for my then-employer using a third-party library which gave us a consistent API across several *nixen and WinNT.