What sort of encryption do you need?

For public key encryption (where the public key encrypts and the private key decrypts), I like Crypt::OpenPGP (though it has a massive ammount of dependencies, including the annoying-to-install Math::Pari).

For good-old block cipher encryption, you probably want Crypt::CBC using Crypt::Rijndael as the underlieing block cipher. Unless you have a need for another cipher mode (if you don't know what this means, look it up, or just use CBC).

For stream ciphers, there is Crypt::RC4. RC4 might have some problems, but there aren't really any better stream ciphers (though most of the time you can drop in a block cipher instead).

If you're just storing some passwords, you probably only need a digest, not a cipher. Try Digest::SHA1.