Two commercial, but reasonably inexpensive Perl-based CMS systems (I've used them both, and each is quite good within its domain)

Article Manager - Good for newspaper/magazine type sites

Big Medium (very flexible layouts - get's you away from the samey look of many CMS systems)

These will get you up and running pretty quickly. But if you want ultimate flexbility, then I guess Bricolage, as suggested above, is best.