This is quite off-topic, since it has nothing really to do with Perl, yet, I'll try to help you out.

Launching a ./Program.pl means, "Please, shell, launch the script Program.pl which is located in ./" The dot-slash means the current directory you're in. You could use /home/Programs/Program.pl in any directory, but that's quite annoying to type every time.

If you set the path in your ~/.tcshrc, as specified, you should be able to call Program.pl without a problem (drop the dot-slash in front of it).

Another thing that strikes me as odd, is the fact that you speak of a ~/.tcshrc (tcshell), yet the error is coming from bash (another shell). So you probably want to add the following line in your ~/.bash_profile:

PATH=$PATH:/home/Programs
export PATH
[download]

This way, you alter the path for bash (which you seem to use anyway). Save these additions to ~/.bash_profile (or ~/.profile) and the next time you login, you can launch your script by typing "Profile.pl" :)

./Program.pl contains a slash. That means, the setting of your path is irrelevant. You ask for the program Program.pl in the current directory to be executed. Which isn't there to begin with. Either use just the name of the program you want to execute, a relative path to the executable, or an absolute path.

Abigail

Also, the *nix way is to create a bin directory in your home directory - /home/user/bin. But maybe your running Mac OS X in which case, /home/user/Applications seems to be the appropriate vendor approach!