I've had only a few minor problems in getting OpenGL.pm and GLUT working with Perl under Win32, which mostly resulted from weird/bad/unforeseen #defines in the various header files.

Other than that, I can't remember what problems there were, but after porting the test files to use GLUT instead of the "proprietary" OS/2 stuff, everything was smooth, even the GLUT callbacks into Perl went without a problem. I did not try to interface to SDL though.