choroba has presented an approach using split and some post-processing of the resultant sub-strings. Here is a regex-based 'extractive' approach that goes after the digits of interest directly and may make it easier to deal with 'messy' strings. See perlre, perlrequick, perlretut.

>perl -wMstrict -le
"my $string = qq{(10 ,12, 14 , 16,18)\n};
 print qq{string is [[$string]]};
 ;;
 my @array = $string =~ m{ \d+ }xmsg;
 printf qq{array (@array) has %d elements \n}, scalar @array;
 ;;
 my $sum = 0;
 $sum += $_ for @array;
 print qq{sum of array is $sum};
 ;;
 my $mean = $sum / @array;
 print qq{mean of array is $mean};
"
string is [[(10 ,12, 14 , 16,18)
]]
array (10 12 14 16 18) has 5 elements
sum of array is 70
mean of array is 14
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