Presumably that will depend on the individual script's use case.

If only 1 of every 1000 runs will perform the conditional require, then it's probably negligible. If 999 of every 1000 runs needs it, then it is probably not negligible.

If in doubt, benchmark!

In reply to Re^3: Use of Autoloader in Modern Times by hippo
in thread Use of Autoloader in Modern Times by Tommy

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