(c/p from excel sheet)

Given that, you may want to consider Spreadsheet::ParseExcel to read the data in directly from your Excel spreadsheet.

Edit: Thanks to the OP for helping me understand the requirements. I now believe this will be much more in line with what you're after:

    my (undef, @col) = split /\t/, <>; # Column names
    my %prob_map;
    while (my ($from, @values) = split /\t/, <>) {
        @{$prob_map{$from}}{@col} = @values;
    }
    say "AAC to AAA = " . $prob_map{AAC}{AAA};
    say "AAA to AAC = " . $prob_map{AAA}{AAC};
__END__
AAC to AAA = 0.011
AAA to AAC = 0.01506

[download]

Previous line-based (i.e., row major) suggestion is below.

Otherwise, parsing the plain text you've provided is fairly straightforward as well:

    my @col   = split /\t/, <>; # Column headings
    my @lines = map { my %l; @l{@col} = split /\t/; \%l } <>;

[download]

However, whether that's actually an improvement on your code or not is debatable. :-)

In reply to Re: Best way to read in an XbyX table into a Hash{Key}{Key2}[value] structure by rjt
in thread Best way to read in an XbyX table into a Hash{Key}{Key2}[value] structure by ZWcarp

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