Mail::Box it is, then.

I searched PerlMonks for "Mail::Box maildir" and came up with a thread titled "Mail::Box fails miserably when trying to open 30_000 messages". But the thread ended with no resolution of the matter.

In light of the thread, perhaps I should break the download from the POP3 server into groups of no more than, say, 20_000 messages? As I mentioned in my original inquiry, I plan to use getmail for the download.

In reply to Re^4: process messages in local maildir + POP3 by exposit
in thread process messages in local maildir by exposit

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