To get around potential memory issues (due to 4-5 Gb files), you can use Tie::File. This will not load the entire file into memory.
That code will be horribly slow.
This single line:
my $last_index = $#locations;
Will cause the entire file to be read through a tiny buffer.
And this line:
my ($chr, $pos) = (split ' ', $locations[$indexes[$rand_index]])[0
+, 1];
will require the disk heads to shuffle back and forth all over the disk to locate the randomly chosen records.
Many parts of the file will be read and re-read many times. Performance will be abysmal.
This algorithm will fairly pick random lines from using a single pass over that file.
With the rise and rise of 'Social' network sites: 'Computers are making people easier to use everyday'
Examine what is said, not who speaks -- Silence betokens consent -- Love the truth but pardon error.
"Science is about questioning the status quo. Questioning authority".
In the absence of evidence, opinion is indistinguishable from prejudice.
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