Not exactly this way, but you could build a hash of hashes of hashes where you could access your data this way:
my %hash;
# ... populate the hash and then possibly something like this:
my $value = $hash{chr1}{1092482}{REF};
But your question is too vague, I can't really offer actual code not knowing what you really want to store in your data structure.
Edit: Not only was choroba (++) faster than me to type an answer, but he did make some hypotheses on the data you need to offer a complete solution.
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