I think it can be done more elegantly, but this works for me

  DB<112> $str ="a123bc45de"
 => "a123bc45de"

  DB<113> join "", reverse map { /\d/ ? $_ : scalar reverse $_ } split
+ /(\d+)/, $str
 => "ed45cb123a"
[download]

HTH! :)

edit

• The split breaks the string into a list of digit and non digit substrings.
• The map does a reverse string (scalar context) on non-digits only
• The join concats the reversed list (list context!) again to a string

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