A question true to your username, so here's a very lazy answer:

perl -i.orig -pe 's/,col6//' FILENAME

It does what you specified by clobbering all instances of ",col6" in the file.

If you want more, read and follow this: How do I post a question effectively?

In reply to Re: Deleting a Column name from file by Anonymous Monk
in thread Deleting a Column name from file by lazy

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