The filter only gets the source that follows the use statement (whether inserted by -M or present in the source), so you can simply use
#!/usr/bin/perl use yX; ...

For example,

$ cat yX.pm package yX; use Filter::Simple sub { tr/n-za-mN-ZA-M/a-zA-Z/; }; 1;
$ cat a.pl #!/usr/bin/perl use yX; cevag("Uryyb, Jbeyq!\a");
$ a.pl Hello, World!

In reply to Re: Hacking a source filter into the #! line by ikegami
in thread Hacking a source filter into the #! line by dcmertens

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