ive used wx in the past and have come to like it pretty good. ppm has everything you need to get up and running. when i first started out i was trying to use these gui builders, but in the long run i finally resorted to scripting the gui manually. the more i worked with it, the more i come to like it. and it can easily be packed into an executable with perlapp or par packer.
Wx has native looks to windows and is pretty much straight forward and has abunch of resources online to look up as well.
Wx + PDK works nicely together :) ... or atleast it has for everything ive done so far.