No. 

$ cat >a.pl
print <DATA>;
__END__
a
b
c

$ perl a.pl
a
b
c

[download]

They're synonymous.

In reply to Re^2: Why shows B::Deparse __END__ as __DATA__? by ikegami
in thread Why shows B::Deparse __END__ as __DATA__? by karlgoethebier

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