Pretty much all of VBA can be translated to Win32::OLE calls, so you can use Microsoft's VBA documentation. Some quick Googling brings me to the Document.DeleteAllComments method, and this works for me:

use Win32::OLE;

my $Word = Win32::OLE->GetActiveObject('Word.Application');
$Word->{ActiveDocument}->DeleteAllComments;

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In reply to Re: Win32:OLE MS-Word comment bubbles by haukex
in thread Win32:OLE MS-Word comment bubbles by mdamazon

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