You can use the shebang to set the environment variables you want: 
#! /bin/sh --
#! -*- perl -*-
eval 'exec env LD_LIBRARY_PATH="/path/to/lib:$LD_LIBRARY_PATH" \
               XML_SIMPLE_PREFERRED_PARSER=XML::Parser \
               PATH="/path1:/path2:/path3:$PATH" \
           perl -x $0 ${1+"$@"}'
    if (0);

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In reply to Re: programatically setting the LD_LIBRARY_PATH by aveckey
in thread programatically setting the LD_LIBRARY_PATH by LanceDeeply

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