While it is certainly true that OP's "sequences" are kind of a database¹, it might be problematic to put them into a database². Of course, once this task is accomplished, it mainly depends on the database³ whether or not threading would help.
database
  1. (general) A collection of (usually) organized information in a regular structure, usually but not necessarily in a machine-readable format accessible by a computer.
  2. (computing) A set of tables in a database(1).
  3. (computing) A software program for storing, retrieving and manipulating a database(1).

In reply to Re^2: Problem in RAM usage while threading the program by soonix
in thread Problem in RAM usage while threading the program by beherasan

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