I know this is an old thread, but I just found it because I am having the same issue. For anyone else who has issues with Win32::SerialPort on a 64 bit system, there is a very simple (3 line edit) patch detailed here which lets you run it on a 64 bit windows system: https://rt.cpan.org/Public/Bug/Display.html?id=113337#txn-1691722

In reply to Re: Serial communication between perl and arduino by cr8josh
in thread Serial communication between perl and arduino by perl_sck_58

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