It's using callbacks from DB:: namespace for each command, so you might be able to write wrappers for Spreadsheet::Read calls and locally replace those callbacks with faster dummies.
No idea how much you'll gain.
I also remember a YAPC talk from some Booking guys about speeding up the debugger, maybe it helps looking there.
see also perldebug, perl5db, perldebguts
Have also a look at DB::sub()
Cheers Rolf
(addicted to the Perl Programming Language :)
Wikisyntax for the Monastery
In reply to Re: Perl Debugger degrades performance when reading large spreadsheet
by LanX
in thread Perl Debugger degrades performance when reading large spreadsheet
by boleary
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