Other than the other optimisations already suggested you might also find speedups using Parallel::ForkManager or MCE::Loop. Any one individual chunk/group of lines taking "a bit longer" could be mitigated by being able to (more easily than from the shell) run against n of them in parallel across the entire file.

The cake is a lie.
The cake is a lie.
The cake is a lie.

In reply to Re: Need to speed up many regex substitutions and somehow make them a here-doc list by Fletch
in thread Need to speed up many regex substitutions and somehow make them a here-doc list by xnous

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