I'm only 9 years late.... But this has just been fixed in DBD::Sybase 1.23 after someone else bumped into the same issue.

In reply to Re: DBI 1.625, DBD::Sybase 1.14, ASE 15.7: no placeholder support for UNSIGNED INT datatype in SET clause by mpeppler
in thread DBI 1.625, DBD::Sybase 1.14, ASE 15.7: no placeholder support for UNSIGNED INT datatype in SET clause by Anonymous Monk

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