Mojolicious itself does not seem to use Perl threads. 
% git remote -v   
origin  git@github.com:mojolicious/mojo.git (fetch)
origin  git@github.com:mojolicious/mojo.git (push)
% ls           
Changes  examples  lib  LICENSE  Makefile.PL  MANIFEST.SKIP  README.md
+  script  t
% rg 'use threads'
% rg 'threads'    
%

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The SQLite docs indicate it may not be suitable if your workflow involves a high degree of concurrent writing, but you'd need to assess/test if you're likely to reach that point.

Using Time::HiRes, you could check how expensive getting the handle really is. Chances are it may not be significant.

In reply to Re: Database access and async web framework (like Mojolicious) by Arunbear
in thread Database access and async web framework (like Mojolicious) by bliako

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