A hash seems the best option in the case described. It is also faster by several orders of magnitude (for your benchmarks, however accurate it may be). 
    my %hash; @hash{0, 15, 16, 31} = ();

    # then add this to your benchmark
    hash => sub {
        while ( $data =~ /^(\d+) (\d+)/mg ) {
            next if exists $hash{$1} or exists $hash{$2};
            return 1;
        }
    },

[download]
             Rate  any_cr     any    ugly ugly_cr   hash2    hash
any_cr      865/s      --    -37%    -54%    -65%   -100%   -100%
any        1382/s     60%      --    -27%    -44%   -100%   -100%
ugly       1896/s    119%     37%      --    -24%   -100%   -100%
ugly_cr    2489/s    188%     80%     31%      --   -100%   -100%
hash    3084047/s 356493% 222992% 162532% 123813%     26%      --

[download]

In reply to Re: Why is "any" slow in this case? by sleet
in thread Why is "any" slow in this case? by Anonymous Monk

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