Version 5.64 of LWP is over 13 years old. Which version are you actually using? And why use both LWP and LWP::Simple? This example works fine for me (using LWP 6.02):

use strict;
use warnings;

use LWP;

my $sku = 49176;
my $url = "https://mms.image.mckesson.com/CumulusWeb/Images/High_Res/$
+sku.jpg";
my $ua = LWP::UserAgent->new;
my $resp = $ua->get($url);
print $resp->code;

[download]

In reply to Re: How can I get images from urls - Getting 443 and 500 errors by hippo
in thread How can I get images from urls - Getting 443 and 500 errors by kevyt

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