I am not sure about what you are trying to accomplish.
A few data lines and expected output would help quite a bit!
Here is one problem that I see: 
#usr/perl -w
use strict;

my $inPath = "somepath";
my $outPath= "outfile";
my $largefile = "large file";

open (INFILE, "<", $path2File) or 
    die "Can't open $path2File for read";

open (OUTFILE, ">", $outPath) or
     die "Can't open $outpath for write";
     
open (LARGE, ">",$largefile) or
     die "Can't open $largefile for write";
     #I don't see why this is necessay!
     
#do something here.... 
while (<INFILE>)
{  ....
   print OUTFILE "some_data\n";
}
     
#in general, open the files that you
#need to use at the beginning of the program and then
#use those file handles. 
#A "re-open" of a file handle for append is very 
#"expensive" thing within a loop in terms of performance.
#Don't do that.

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In reply to Re: Out of Memory Error : V-Lookup on Large Sized TEXT File by Marshall
in thread Out of Memory Error : V-Lookup on Large Sized TEXT File by TheFarsicle

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