You can go full out with Catalyst and Class::DBI DBIx::Class (edit: i dislike both and avoid ORMs in general although i have found that Ruby's Active Record solution takes care of the duplicity problem) but i would look at either Dancer or Mojolicious::Lite to create your framework. You most likely will want to incorporate some AJAX calls and such frameworks help to keep your code clean. I also recommend using Template::Toolkit as your templating engine but as long as you are using a templating engine then you should be better off than not. There are plenty of CPAN modules that allow you to communicate with database servers et. al. And last but not least, use Twitter Bootstrap to handle dynamic JS and CSS styling and help with AJAX and JQuery calls.

L-LL-L--L-LL-L--L-LL-L--
-R--R-RR-R--R-RR-R--R-RR
B--B--B--B--B--B--B--B--
H---H---H---H---H---H---
(the triplet paradiddle with high-hat)