Perl's core modules include 'Memoize', which attempts to make functions faster by "trading space for time."

http://perldoc.perl.org/Memoize.html

But I'd have to do trial-and-error to see what worked. (I'm wondering if a regExp would be faster than split) 
     /.*,.*,.*,.*,.*,.*,.*,.*,(*),.*/  
       my $X = $1

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Then you wouldn't even need to call chomp. (And in general, I'm wondering if it would speed things up to combine the other instructions.) 
    chomp( my($line)=$_ ) ;

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UPDATE: It occurred to me that the code re-declares every variable again on every pass through the loop. It seems like it might help to try 
my ($X, $Y, $A, $B, $C, $D);
while(<DATAIN>)

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In reply to Re: Optimizing perl code performance by Intermediate Dave
in thread Optimizing perl code performance by usertest

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