One way to one step per regex: 

c:\@Work\Perl>perl -wMstrict -le
"my $c = q{asdfghjk};
 print qq{    original: '$c'};
 ;;
 my @regex = (
   { lh => q{(gh)}, rh => q{__$1__}, },
   { lh => q{(h_)}, rh => q{_h!$1!}, },
   );
 ;;
 for my $hr_s (@regex) {
   $c =~ s[ (?-x)$hr_s->{lh}]{ qq{qq{$hr_s->{rh}}} }xmsgee;
   print qq{intermediate: '$c'};
   }
 ;;
 print qq{       final: '$c'};
"
    original: 'asdfghjk'
intermediate: 'asdf__gh__jk'
intermediate: 'asdf__g_h!h_!_jk'
       final: 'asdf__g_h!h_!_jk'

[download]
Since  s///e or  s///ee is string eval, AnonyMonk's warning/advice here still holds. See Re: Evaluating $1 construct in literal replacement expression and associated nodes for more discussion.

Give a man a fish:  <%-{-{-{-<

In reply to Re^3: Regex stored in a scalar by AnomalousMonk
in thread Regex stored in a scalar by OtakuGenX

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