I ran this on the OP's data set and it looks like it gives the correct answer, but also throws a couple of warnings in the process. I haven't quite figured out why? Update, new code, try to eliminate warnings... Original code... 
#!usr/bin/perl
use warnings;
use strict;
$|=1;

my $line = '1925,47365,2,650187016,1,1,"MADE FOR DRAWDOWNS, NEVER P/U"
+,16,IFC 8112NP,Standalone-6,,,44,10/22/2015,91607,,B24W02651,,"PA-3, 
+PURE",4/28/2015,1,0,,1,MAN,,CUST,,CUSTOM MATCH,0,TRUE,TRUE,O,C48A0D00
+1EF449E3AB97F0B98C811B1B,POS.MISTINT.V0000.UP.Q,PROD_SMISA_BK,414D512
+050524F445F504F5331393235906F28561D2F0020,10/22/2015 9:29,10/22/2015 
+9:30';

my $i=0;
my $line2 = join '', grep { $i++ % 2 ? {s/,/ /g} : 1} split /"/,$line;

print "line 1=$line\n";
print "line 2=$line2\n";

__END__
Odd number of elements in anonymous hash at C:\Projects_Perl\handledou
+blequotecsv.pl line 9.
Odd number of elements in anonymous hash at C:\Projects_Perl\handledou
+blequotecsv.pl line 9.
line 1=1925,47365,2,650187016,1,1,"MADE FOR DRAWDOWNS, NEVER P/U",16,I
+FC 8112NP,Standalone-6,,,44,10/22/2015,91607,,B24W02651,,"PA-3, PURE"
+,4/28/2015,1,0,,1,MAN,,CUST,,CUSTOM MATCH,0,TRUE,TRUE,O,C48A0D001EF44
+9E3AB97F0B98C811B1B,POS.MISTINT.V0000.UP.Q,PROD_SMISA_BK,414D51205052
+4F445F504F5331393235906F28561D2F0020,10/22/2015 9:29,10/22/2015 9:30
line 2=1925,47365,2,650187016,1,1,MADE FOR DRAWDOWNS  NEVER P/U,16,IFC
+ 8112NP,Standalone-6,,,44,10/22/2015,91607,,B24W02651,,PA-3  PURE,4/2
+8/2015,1,0,,1,MAN,,CUST,,CUSTOM MATCH,0,TRUE,TRUE,O,C48A0D001EF449E3A
+B97F0B98C811B1B,POS.MISTINT.V0000.UP.Q,PROD_SMISA_BK,414D512050524F44
+5F504F5331393235906F28561D2F0020,10/22/2015 9:29,10/22/2015 9:30

[download]
New version with OP's input line: 
#!usr/bin/perl
use warnings;
use strict;
$|=1;

my $line = '1925,47365,2,650187016,1,1,"MADE FOR DRAWDOWNS, NEVER P/U"
+,16,IFC 8112NP,Standalone-6,,,44,10/22/2015,91607,,B24W02651,,"PA-3, 
+PURE",4/28/2015,1,0,,1,MAN,,CUST,,CUSTOM MATCH,0,TRUE,TRUE,O,C48A0D00
+1EF449E3AB97F0B98C811B1B,POS.MISTINT.V0000.UP.Q,PROD_SMISA_BK,414D512
+050524F445F504F5331393235906F28561D2F0020,10/22/2015 9:29,10/22/2015 
+9:30';

my $i=0;
my $line2 = join '', grep { $i++ % 2 ? {s/,/ /g} : 1} split /"/,$line;


print "line 1=$line\n";
print "line 2=$line2\n";

my $j=0;    # recoded into a slightly different way...
my @csv;
foreach (split /"/,$line)
{
   s/,/ /g if $j++ % 2;
   push @csv, $_;
}
print "\n\n$line\n";
print @csv,"\n";
__END__
first version, 2 warnings....
Odd number of elements in anonymous hash at C:\Projects_Perl\handledou
+blequotecsv.pl line 9.
Odd number of elements in anonymous hash at C:\Projects_Perl\handledou
+blequotecsv.pl line 9.
line 1=1925,47365,2,650187016,1,1,"MADE FOR DRAWDOWNS, NEVER P/U",16,I
+FC 8112NP,Standalone-6,,,44,10/22/2015,91607,,B24W02651,,"PA-3, PURE"
+,4/28/2015,1,0,,1,MAN,,CUST,,CUSTOM MATCH,0,TRUE,TRUE,O,C48A0D001EF44
+9E3AB97F0B98C811B1B,POS.MISTINT.V0000.UP.Q,PROD_SMISA_BK,414D51205052
+4F445F504F5331393235906F28561D2F0020,10/22/2015 9:29,10/22/2015 9:30
line 2=1925,47365,2,650187016,1,1,MADE FOR DRAWDOWNS  NEVER P/U,16,IFC
+ 8112NP,Standalone-6,,,44,10/22/2015,91607,,B24W02651,,PA-3  PURE,4/2
+8/2015,1,0,,1,MAN,,CUST,,CUSTOM MATCH,0,TRUE,TRUE,O,C48A0D001EF449E3A
+B97F0B98C811B1B,POS.MISTINT.V0000.UP.Q,PROD_SMISA_BK,414D512050524F44
+5F504F5331393235906F28561D2F0020,10/22/2015 9:29,10/22/2015 9:30

2nd version no warnings....
1925,47365,2,650187016,1,1,"MADE FOR DRAWDOWNS, NEVER P/U",16,IFC 8112
+NP,Standalone-6,,,44,10/22/2015,91607,,B24W02651,,"PA-3, PURE",4/28/2
+015,1,0,,1,MAN,,CUST,,CUSTOM MATCH,0,TRUE,TRUE,O,C48A0D001EF449E3AB97
+F0B98C811B1B,POS.MISTINT.V0000.UP.Q,PROD_SMISA_BK,414D512050524F445F5
+04F5331393235906F28561D2F0020,10/22/2015 9:29,10/22/2015 9:30
1925,47365,2,650187016,1,1,MADE FOR DRAWDOWNS  NEVER P/U,16,IFC 8112NP
+,Standalone-6,,,44,10/22/2015,91607,,B24W02651,,PA-3  PURE,4/28/2015,
+1,0,,1,MAN,,CUST,,CUSTOM MATCH,0,TRUE,TRUE,O,C48A0D001EF449E3AB97F0B9
+8C811B1B,POS.MISTINT.V0000.UP.Q,PROD_SMISA_BK,414D512050524F445F504F5
+331393235906F28561D2F0020,10/22/2015 9:29,10/22/2015 9:30

Process completed successfully

[download]
Of course @csv chould be joined back together since it was split on '"' instead of ',' and then re-split on comma. This algorithm does appear to work when reformulated and does its job of getting rid of commas within double quotes without run-time warnings. Replacing the "," with a space might not be the "best". possible improvement is to reduce multiple spaces to single spaces.

In reply to Re^2: Replace commas with spaces between quotes, parsing CSV by Marshall
in thread Replace commas with spaces between quotes, parsing CSV by BigRedEO

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