12,6 min on my side with a newer perl, same distro like yours : 
:perl -v

This is perl 5, version 22, subversion 1 (v5.22.1) built for MSWin32-x
+64-multi-thread
(with 1 registered patch, see perl -V for more detail)

Copyright 1987-2015, Larry Wall

Binary build 2201 [299574] provided by ActiveState http://www.ActiveSt
+ate.com
Built Jan  4 2016 12:12:58

[download]
Could you give me your time with this code and the same file (http://mab.to/tbT8VsPDm) perl demo.pl 
open (FH, '<', "../Tests/10-million-combos.txt");
$counter=0;
$counter2=0;
while (<FH>) {
    if (/123456$/) {++$counter2;}
}
    print "\n";
print "Num. Line : $. - Occ : $counter2\n";
close FH;

[download]
Thanks.

In reply to Re^7: How to optimize a regex on a large file read line by line ? by John FENDER
in thread How to optimize a regex on a large file read line by line ? by John FENDER

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