the method OnInit is not called

Try changing the declarator `sub` to `method`: 

class YTDL::App is Wx::App
{
  method OnInit {
    say "***";
    return True;
  }
}

[download]

If that doesn't fix things, or if you have other questions, the freenode #perl6 IRC channel is currently by far the best place to go for talking through any problems you're having while working with anything to do with Perl 6.

In reply to Re: [Perl6] Problem using Inline::Perl5 by raiph
in thread [Perl6] Problem using Inline::Perl5 by holli

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