If perl compiles and passes tests on the target OS, is there any reason to fear that problems exist?

Or perhaps you are concerned about specific modules in the perl ecosystem? In that case, bug reports or CPAN Testers reports for the distribution in question would seem to be the authoritative source for such information.

In reply to Re: Perl on Sierra (Mac OS X 10.12.x): any issues? by gnosti
in thread Perl on Sierra (Mac OS X 10.12.x): any issues? by kcott

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