If you're thinking of something like Zope, there are two Perl-based projects of which I'm aware:
Iaijutsu, which is a pretty complex system, with lots of features.
Jellybean, which is my take on things. It's a lot simpler, but hasn't been under development as long.
Another option I've been studying is Entity, which would need some sort of HTTP interface before it will do what you want. Your quickest bet is probably HTML::Mason (follow the link to CPAN).