Thank you very much,cookersjs! I make the minicpan works following your advice. I installed BioPerl successufly with local mirror of CPAN, but when I run perl INSTALL.PL to install VEP, it still report the same error log:

Destination directory ./Bio already exists.
Do you want to overwrite it (if updating VEP this is probably OK) (y/n
+)? y
 - fetching BioPerl
curl: (6) Couldn't resolve host 'github.com'
 - unpacking ./Bio/tmp/release-1-6-924.zip
format error: file is too short
 at /home/schexy/localperl/lib/perl5/Archive/Zip/Archive.pm line 692.
        Archive::Zip::Archive::_findEndOfCentralDirectory(Archive::Zip
+::Archive=HASH(0x133dea0), IO::File=GLOB(0x133dd20)) called at /home/
+schexy/localperl/lib/perl5/Archive/Zip/Archive.pm line 591
        Archive::Zip::Archive::readFromFileHandle(Archive::Zip::Archiv
+e=HASH(0x133dea0), IO::File=GLOB(0x133dd20), "/home/schexy/software/e
+nsembl-tools-release-87/scripts/varian"...) called at /home/schexy/lo
+calperl/lib/perl5/Archive/Zip/Archive.pm line 559
        Archive::Zip::Archive::read(Archive::Zip::Archive=HASH(0x133de
+a0), "/home/schexy/software/ensembl-tools-release-87/scripts/varian".
+..) called at /home/schexy/localperl/lib/perl5/Archive/Extract.pm lin
+e 1153
        Archive::Extract::_unzip_az(Archive::Extract=HASH(0x189b718)) 
+called at /home/schexy/localperl/lib/perl5/Archive/Extract.pm line 43
+1
        Archive::Extract::extract(Archive::Extract=HASH(0x189b718), "t
+o", "./Bio/tmp/") called at INSTALL.pl line 1526
        main::unpack_arch("./Bio/tmp/release-1-6-924.zip", "./Bio/tmp/
+") called at INSTALL.pl line 639
        main::bioperl() called at INSTALL.pl line 246
        main::api() called at INSTALL.pl line 221
Unable to read '/home/schexy/software/ensembl-tools-release-87/scripts
+/variant_effect_predictor/Bio/tmp/release-1-6-924.zip' at INSTALL.pl 
+line 1526.
Unable to unzip '/home/schexy/software/ensembl-tools-release-87/script
+s/variant_effect_predictor/Bio/tmp/release-1-6-924.zip':

[download]

It seems like the problem is the INSTALL.PL cannot find my installed BioPerl, so it goes to github to download. Could you please give me some suggestions about how to fix this? Looking forward to hearing from you. Thanks again!

In reply to Re^7: Installation error; INSTALL.pl program is unable to unzip downloaded file by Holly He
in thread Installation error; INSTALL.pl program is unable to unzip downloaded file by cookersjs

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