Since your specifications are quite fuzzy, I made assumptions toward simplicity, and offer the following code: 
use strict;
use warnings;

# Open the files specified in @AGV
$ARGV[0] or die "ERROR: No file for 114 lines";
$ARGV[1] or die "ERROR: No file for 300K lines";$ARGV[2] or die "ERROR
+: No Output file name";
open my $smallfile,"<",$ARGV[0] or die "ERROR: COuld not open small fi
+le $ARGV[0]:$!";
open my $bigfile,"<",$ARGV[1] or die "ERROR: COuld not open large file
+ $ARGV[1]:$!";
open my $outfile,">",$ARGV[2] or die "ERROR: COuld not open output fil
+e $ARGV[2]:$!";
 
my $search_expression = "";
while(<$smallfile>){
    chomp;
    next unless length; # skip if empty
    $search_expression .="\Q$_\E|";
}
close $smallfile;
chop $search_expression; # Delete extra "|"
$search_expression = qr($search_expression);
my $found_lines = 0;
#Perform the search
while (<$bigfile>){
    next unless m/$search_expression/; 
    # We have a matching line
    print $outfile $_;
    $found_lines++;
}
close $bigfile;
close $outfile;
print "Created $found_lines lines of output in $ARGV[2]\n";

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In reply to Re: searching in large file by NetWallah
in thread searching in large file by sabas

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