Not only it does make sense, it is also necessary if you want a "snappy" UI: there is plenty of information on the topic (https://www.perlmonks.org/?node=Tk+thread), many discuss exactly what you're trying to achieve, e.g.: PerlTk on a thread... Need help in using threads in Tk

In reply to Re^4: LWP::UserAgent timeout by markong
in thread LWP::UserAgent timeout by IB2017

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