bliako, what an interesting subject matter! As of yet, I'm unable to follow you. My first problem is that I get nothing from the wget command:

$ wget ftp://ftp.ncbi.nih.gov/genomes/Homo_sapiens/CHR_20/hs_ref_GRCh3
+8.p12_chr20.fa.gz
--2019-01-23 07:54:51--  ftp://ftp.ncbi.nih.gov/genomes/Homo_sapiens/C
+HR_20/hs_ref_GRCh38.p12_chr20.fa.gz
           => ‘hs_ref_GRCh38.p12_chr20.fa.gz’
Resolving ftp.ncbi.nih.gov (ftp.ncbi.nih.gov)... 130.14.250.12, 2607:f
+220:41e:250::12
Connecting to ftp.ncbi.nih.gov (ftp.ncbi.nih.gov)|130.14.250.12|:21...
+ failed: Connection timed out.
Connecting to ftp.ncbi.nih.gov (ftp.ncbi.nih.gov)|2607:f220:41e:250::1
+2|:21... failed: Network is unreachable.
$

[download]

I took some care that newlines, spaces and plusses were removed from the foldover effect, but that is error-prone. I do see 'nih' in the url and suspect that it might be closed because of Orange Ulbricht.(?)

I can't call the package properly. I usually don't have packages with scope, so I don't know what to do with this. I tried to imitate what cpan does for module and then use as a lib. Perl isn't impressed:

$ mkdir Markov
$ cd Markov/
$ touch Ndimensional.pm
$ gedit Ndimensional.pm &
[1] 20524
$ pwd
/home/bob/2.scripts/pages/7.cw/template_stuff/crosswords/eugene/Markov
[1]+  Done                    gedit Ndimensional.pm
^^^^ pasted in source
$ cd ..
$ ls
1.bliako.pl  bliako1.pm  Markov
$ ./1.bliako.pl 
Can't locate Markov/Ndimensional.pm in @INC (you may need to install t
+he Markov::Ndimensional module) (@INC contains: Markov /home/bob/perl
+5/lib/perl5/x86_64-linux-gnu-thread-multi /home/bob/perl5/lib/perl5 /
+etc/perl /usr/local/lib/x86_64-linux-gnu/perl/5.26.1 /usr/local/share
+/perl/5.26.1 /usr/lib/x86_64-linux-gnu/perl5/5.26 /usr/share/perl5 /u
+sr/lib/x86_64-linux-gnu/perl/5.26 /usr/share/perl/5.26 /usr/local/lib
+/site_perl /usr/lib/x86_64-linux-gnu/perl-base) at ./1.bliako.pl line
+ 13.
BEGIN failed--compilation aborted at ./1.bliako.pl line 13.
$

[download]

, where caller looks like this:

$ cat 1.bliako.pl 
#!/usr/bin/env perl

# FILE: analyse_DNA_sequence.pl
# by bliako

use strict;
use warnings;

use Getopt::Long;
use Data::Dump qw/dump/;
use lib 'Markov';

use Markov::Ndimensional;

[download]

My question then is whether the download is there for anyone else and where to put Ndimensional.pm and how to call it correctly.

I think it's a way in which perl truly is relevant.

In reply to Re: n-dimensional statistical analysis of DNA sequences (or text, or ...) by Aldebaran
in thread n-dimensional statistical analysis of DNA sequences (or text, or ...) by bliako

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