If all your columns are fixed-width, you can use unpack 

use strict;
use warnings;

while(<DATA>) {
    my ($colA, $colB, $colC,$colD) = unpack "A19A15A7A45";
    $colC = "N/A" if $colC eq "XYZ" and $colD =~ /Region/;
    print "$colA -- $colB -- $colC -- $colD\n";
}

__DATA__
ValuesInColumn1    DataColumnB    XYZ    RowDescription|RowCode|Suppli
+er ID::Region
ValuesInColumn1    DataColumnB    XYZ    RowDescription|RowCode|Suppli
+er ID::Region
ValuesInColumn1    DataColumnB    XYZ    RowDescription|RowCode|Suppli
+er ID::Region
ValuesInColumn1    DataColumnB    XYZ    RowDescription at RowCode
ValuesInColumn1    DataColumnB    ABC    RowDescription at RowCode

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In reply to Re: Split lines in file to columns by hdb
in thread Split lines in file to columns by Magnolia25

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