Could you give a bit more details about just what those /..../ bits really are?

• Are they constant? (i.e. /abcd/, not containing any interpolated variables; if so then they'll be compiled once and you don't have anything to worry about (just covering that base because of the vagueness))
• Do they depend on something determinied at runtime, but that doesn't vary from line to line? If so, then compile them once with a $res = prepare_regexen() that populates a hash; then use if( m/$res->{CONDITION_ONE} / ) { ... }
• Do they vary from line to line? In this case you're probably screwed, but you might can make gains by factoring out common subexpressions and precompiling those.
• Consider whether you really need regular expressions, or if you can replace some with index instead.

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