I just recently had that problem myself.

Edit Makefile.PL and where it has something similar to "/usr/bin/mysql_config"

change it to where your mysql_config is actually located per your mysql install.

That should fix it for you.
update: Look on line 169 of Makefile.PL 
perl -e '$_=$0;split??;chop$_;$;=pop@_;$;++for(0..9060420);$_.=reverse
+$;;print'

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In reply to Re: Problems installing DBD::mysql by xylus
in thread Problems installing DBD::mysql by dthacker

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