You didn't post any code, so it's very hard to say. Perhaps
you are already using the fastest solution, which only leaves
the answer: upgrade your hardware.
And perhaps you are doing something stupid. Then you don't
need any clever tricks, you just have to get rid of the
stupidity.
And who knows, perhaps you don't need a regexp at all.
Maybe you can put the 300 keywords into a hash, and extract
all the words from the document, looking for a match. But
it will depend on what the keywords are whether that is
possible.
Also, is there a way of measuring the execution time of perl scripts without letting the script complete its run?
No, because if the answer would be 'yes', one could solve
the halting problem - which is unsolvable.
Abigail
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