Anonymous Monk,
The answer is yes, but you probably want something for the general case as well as this specific case. 
#!/usr/bin/perl -w
use strict;

my $string = 'John is following jane';

# Specific 
$string =~ s/[jJ]ane/##Jane##/;

# To preserve j or J in replacement
# $string =~ s/([jJ]ane)/##$1##/;

# More generic
# $string =~ s/(John is following) (\w+)/$1 \u$2/;

[download]
Cheers - L~R

In reply to Re: Regex: Case insensitive search but case sensitive replace by Limbic~Region
in thread Regex: Case insensitive search but case sensitive replace by Anonymous Monk

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